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Inadequate/Considerable Metabolizers, CYP2D6 The development on the Lively metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. About 7% on the populace has diminished exercise in the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme method. These people are “inadequate metabolizers” of debrisoquine, dextromethorphan and tricyclic